UMF - Universitatea de Medicina si Farmacie "Carol Davila" Bucuresti

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PhD Topics 2010-2011

In order to pass the written test of theoretical knowledge verification, the Council of Doctoral Studies with the consent of the Speciality Committees communicates the following topics:

    * Surgical Specialties
          - Esophageal cancer - diagnosis and treatment principles
          - Main bile duct lithiasis - diagnosis and treatment principles
          - Principles of oncological surgery of the colorectal tumors
          - Liver hydatid cyst - diagnosis and treatment
          - Burns classification based on etiology, depth and surface
          - Cranio-cerebral injuries - principles and treatment
          - Acute peripheral ischemia - treatment principles
          - Metastatic prostate cancer - diagnosis and treatment principles
          - Broncho-pulmonary suppurations - diagnosis and treatment principles
          - Etiopathogenesis of the premature birth

 Bibliography
          - Ancar V., Ionescu C. - Obstetrics, National Publishing House 1999
          - N. Angelescu (under red.) - Treaty of surgical pathology, Medical Publishing House, Bucharest, vol I and II 2001
          - Gherasim L. (under red.) - Medical practice guidelines, the College of Physicians in Romania, Infomedica Publishing House, Bucharest, Vol II, p. 141-151, 2001
          - Harrison - Principles of Internal Medicine, 14th edition, Teora Publishing House, Bucharest 2003 (reprint of 2001 edition)
          - Harrison - Principles of Internal Medicine, 16th edition, selective translation by Medical Publishing House 2005
          - Sinescu I. - Urologic Oncology, University Publishing House "Carol Davila" 2006


    * Medical Specialties
          - Primitive and secondary pulmonary hypertension
          - Chronic viral hepatitis and nonvirale
          - Acute coronary syndromes
          - Cardiac failure: progression factors and their treatment
          - Metabolic syndrome
          - Neurological complications in metabolic diseases
          - Collagenosis (SLE and rheumatoid polyarthritis)
          - Child's congenital diseases
          - Rhythm and growth disorders
          - Glomerular nephropathy
      Bibliography
          - L. Gherasim - Treaty of internal medicine (last edition)
          - E. Ciofu - Essential in pediatrics, 2nd edition, 2002
          - Harrison - Treaty of Internal Medicine (latest edition)


    * Anatomy
          - Vegetative nervous system
          - Peripheral nervous system
          - Central nervous system
          - Cord - vascular system
          - Digestive apparatus and the annex organs
          - Respiratory apparatus
          - Urogenital apparatus
          - Locomotor apparatus - structure, biomechanics
          - Endocrine glands
          - Embryogenesis concepts - abnormalities and congenital malformations
      Bibliography
      You can use any manual that uses international anatomical nomenclature
          - Gray's Anatomy
          - Human Anatomy vol I, 1, 2, 3; vol II. 1, 2; in red. Prof. Dr. V. Ranga
          - Human Anatomy under red. of Prof. Dr. Alex. I. Ispas
          - Functional anatomy of the nervous system - A. Andronescu
          - Human Anatomy - V. Papilian, Vol 1, Vol 2


    * Biophysics
          - Passive transport phenomena across the cellular membranes
          - Active transport mechanisms across the cellular membrane
          - Membrane receptors
          - Cellular resting potential
          - Cellular action potential
          - Visual photoreception Biophysics
          - Auditory reception Biophysics
          - Lasers biomedical applications
          - Methods of investigation of the cellular electrical activity (electrophysiological techniques: patch-clamp, BLM)
          - NMR imaging physical principles
      Bibliography
          - Constanta Ganea - Medical Biophysics, 2004; biofizica.dyndns.org
          - Alberts & the collab. 2002 - Molecular Biology of the Cell, Garland Science Publishing House
          - Pollard and Earnshaw - Cell Biology 2002, Elsevier Publishing House
          - E. Kovacs & the collab. - Biophysics and Cell Biotechnology. Research Methods 2002, Carol Davila Publishing House
          - Eremia D. - medical biophysics course UMF "Carol Davila" Bucharest 1993
          - S. Herman - Physical principles of the modern medical equipment, 1999, Teora Pub. House
          - Dimoftache C., S.Herman - Principles of Human Biophysics,  "Carol Davila" Pub. House Bucharest 2003


    * Pharmacology
          - General Pharmacodynamics
          - General pharmacokinetics
          - Cholinergic system
          - Adrenergic system
          - Antipsychotics
          - Opioid analgesics and antagonists
          - Antiarrhythmics
          - Diuretics
          - Antiviral chemotherapeutic agents
          - Anticancer chemotherapeutic agents and immunosuppressants
      Bibliography
          - Ion Fulga - Pharmacology, Medical Publishing House, Bucharest, 2004 or 2006


    * Molecular and Cellular Medicine
          - Endocytosis
          - Cellular membrane. Receptors
          - Cellular cycle. Control Mechanisms
          - Extracellular matrix
          - Cellular secretion
          - Cito-Skeleton
          - Pigment cells
          - Synapses ultrastructure and molecular conformation
          - Apoptosis
          - Stem Cells
      Bibliography
          - B. Alberts & the collab. - Molecular Biology of the Cell, Garland Science Publishing House 2002
          - L.C. Junqueira & the collab. - Basic Histology. Text & Atlas, Lange Medical, 2003 McGraw-Hill Companies


    * Physiology
          - Cell Physiology
          - Heart physiology
          - Physiology of cerebral circulation
          - Signal transmission and processing in the nervous system
          - Hydroelectrolytic balance
          - Neurotransmitters
          - Respiratory physiology
          - Endocrine system physiology
          - Immune response
          - Metabolism physiology
      Bibliography
          - Guyton & Hall - Textbook of Medical Physiology the 11th Edition 2005
          - Zagrean L. - Clinical Neuroelectrophysiology 2005
          - Boron & Boulpaep - Medical Physiology, The 1st Edition 2003
          - Zagrean L. - Neuroscience. Fundamentals 2002
          - E. Kandel - Principles of Neural Sciences, the 4th Edition 2000


    * Specialties of Pathophysiology and Immunology
          - Normal and pathological postagressive cellular reaction
          - Normal and pathological postagressive tissue reaction (hemostasis, inflammation)
          - Normal and pathological postagressive systemic reaction
          - Hydroelectrolytic and acid-base balance to normal and pathological conditions
          - Primary / secondary dyslipidemia and atherosclerosis
          - Humoral immune response to normal and pathological conditions
          - Complement answer to normal and in pathological conditions
          - Cellular immune response to normal and pathological conditions
          - Immunological tolerance and autoimmune pathology
          - Antitumor/ anticancer immune defense
      Bibliography
          - Pathophysiology - The Biological Basis for Disease in Adults and Children Huether McCance
          - Pathophysiology - Aletered Regulatory Mechanisms in Disease - Edward Fröhlich
          - Pathophysiology of  Disease - Stephen McPhee
          - Biologie moleculaire - Bichimie des communications cellulaire - Ch. Moussard
          - Biologie moleculaire de la cellule - Bruce Alberts
          - Immunobiology - Ch. Janeway, P. Travers
          - Cellular and Molecular Immunology - Adbul Abbas
          - Immunology - Ivan Roitt, J. Brostoff, D. Male
          - Immunology - J. Kuby
          - Esential de imunologie - C. Bara


    * Microbiology
          - Morphology and structure of bacteria (General)
          - Resistance of microorganisms to the physical, chemical and biological agents and their applications
          - Micro-aggression; pathogenic mechanisms
          - Immune response and its applications in the etiological diagnosis
          - Bacteriological diagnosis in acute infectious diarrhea syndrome
          - Streptococcal infections: laboratory diagnosis
          - Laboratory diagnosis of staphylococcal infections
          - Laboratory diagnosis of tuberculosis infection
          - Parenteral transmission diseases: etiologic diagnosis (principles)
          - Anaerobic bacteria: implications in human pathology
      Bibliography
          - D. Buiuc, M. Negut - Treaty of Clinical Microbiology, Medical Publishing House 1999
          - D. Buiuc - Clinical Microbiology, Didactic and Pedagogic Publishing House 1998
          - Murray P., Baron R.P., Pfaller A.M., Fenover C.F., Yolken H.R. - Manual of clinical microbiology, ASM Press 1999
          - Topley and Wilson - Microbiology and Microbial Infection, Ed IX Vol 3, Bacterial Infection, Arnold Publishing House 1998


    * Medical Psychology
          - Concept of physical and mental health. Bio-psychosocial model
          - Salutogenetic and pathogenetic disease behaviors
          - Eustress and ditress. Similarities and differences in terms of clinical and psychoneuroendocrinoimunologic
          - Types of coping during a distress caused by a chronic disease
          - Patient's cognitive representations of illness after Leventhal
          - Attitude and behavior changes occured during severe illness
          - Social status of the patient and the doctor after Parsons
          - Psychological reactions induced by the administration and the effects of drugs
          - Therapheutic compliance and psychosocial factors that generate it
          - Simple supportive psychotherapy and receptive music therapy
      Compulsory Bibliography
          - * I.B. Iamandescu - Health Psychology, Infomedica Publishing House, Bucharest 2005
          - ** B. Luban Plozza and I.B. Iamandescu (under red.) - Psychosocial size of the medical practice, Infomedica Publishing House Bucharest 2002
          - ** I.B. Iamandescu (under red.) - Elements of General and Applied Psychosomatics, Infomedica Publishing House Bucharest 1999
      Optional Bibliography
          - Tudose Florin - A modern approach of the medical psychology, Infomedica Publishing House, Bucharest 1998
          - Iuliana Dobrescu - Child and Adolescent Psychiatry, Medical Publishing House, Bucharest 2003
          - ** I.B. Iamandescu - Medical Psychology, Infomedica Publishing House Bucharest 2003
          - G. Ionescu - Psychotherapy, Scientific and Encyclopedic Publishing House Bucharest 1990
          - * I.Gr. Popescu - Introduction to Medical Semiology. Chapter "Psychological approach of the patient" (Psychosomatic semiology), Medical Life Publishing House, Bucharest 2002, p. 243-239
          - Romila A. - Psychiatry, ed. II, Free Psychiatrists Publishing House, Bucharest 2004
      Note! - * The book can be obtained at the Department of Medical Psychology (Colentina Hospital)
      ** Books exhausted (can be the found in the library of the UMF "Carol Davila")
      The subjects of the curriculum are covered fully in I-1; II-5


    * Specialty Dentistry
          - Determination of the intermaxillary relationship in the total edentulous
          - Total edentulous prosthetic field
          - Partial edentulous treatment stages
          - Pain in the oro-maxillo-facial territory
          - Prosthetic Surgery
          - Main therapeutic directions and treatment schemas in the marginal periodontal diseases
          - Morphology of the marginal periodontal
          - Anatomic-clinical forms of permanent teeth pupils
          - Facial massive fractures
          - Etiopathogenesis of the dental caries
      Optional Bibliography
          - D. Bratu, Nussbaum - Clinical and technical bases of fixed prosthetics, Medical Publishing House 2003 or Helicon Publishing House 2001 Timisoara
          - C. Burlibasa - Oral and maxillofacial surgery, Medical Publishing House, Bucharest 1991
          - H.T. Dumitriu - Periodontology, 3rd Edition, Romanian Medical Life Publishing House, Bucharest 1991
          - A. Iliescu, M. Gafar - Cariology and restorative otodontotherapy, Medical Publishing House Bucharest 2001
          - Gafar M., A. Iliescu - Clinical and practical endodontics, Ed II, Medical Publishing House Bucharest 2002
          - E. Hutu - Total edentulism, ed. III, Didactic and Pedagogic Publishing House 1998
          - A. Ionescu - Clinical and laboratory technique of the scaffold prosthesis, vol I and II,  Cerma Publishing House Bucharest 1997
          - S. Ionita, A. Petre - Dental occlusion, Didactic and Pedagogic Publishing House, Bucharest 1997
          - Rodica Luca - Local methods of caries prevention from grooves and fissures, Cerma Publishing House Bucharest 1997
          - Gh Boboc - Dentamaxilar device. Formation and Development, Medical Publishing House, Bucharest 1995
      Pharmaceutical Specialties written test

    * Chemical Pharmaceutical Sciences
          - Concepts regarding the chemical bonds in combinations of inorganic nature.
          - Complex combinations with biomedical implications.
          - Stereochemistry. Conformation and stereoselectivity. The use of spectral methods in determining the structure of organic compounds.
          - Penta-atomic heterocyclic compounds containing nitrogen, sulfur and oxygen atoms in the molecule. Biological importance.
          - Functional derivatives of carboxylic acids. Summary. Properties. Compounds of biological interest.
          - Molecular absorption spectrometry in UV-Vis in pharmaceutical analysis.
          - Liquid chromatography in pharmaceutical analysis.
          - Classes of anxiolytic drugs (Tranquilizers).
          - Classes of antipsychotic drugs (neuroleptics).
          - Classes of antidepressant drugs.


      Bibliography
          - Veronica Nacea, Rica Boscenco, Inorganic Chemistry, Fundamentals, Carol Davila University Publishing House, Bucharest, 2010;
          - Ioana Saramet, Valeria Radulescu - Fundamentals of Organic Chemistry, vol I and vol II, Tehnoplast Publishing Company, Bucharest, 2006;
          - Mircea Iovu: Organic Chemistry, fifth edition, Bucharest, 2005;
          - Pietrzyk, D. J., Franck, C. W,, Analytical Chemistry, Technical Publishing House, Bucharest, 1989;
          - Skoog, D.A., Holler, F.J., Nieman, T.A., Principles of Instrumental Analysis, 5th ed., Philadelphia, Saunders College Publishing, 1998;
          - Kellner, R., Mermet, J.-M., Otto, M., Valcarcel, M., Widmer, H.M., Analytical Chemistry: A Modern Approach to Analytical Science, 2nd ed., Wiley-VCH, Weinheim, 2004;
          - Marius Bojita, Liviu Roman, Robert Sandulescu, Radu Oprean,Analysis and control of drugs, vol. I and vol. II, Intelcredo Publishing House, Deva, 2003;
          - European Pharmacopoeia, sixth edition;
          - Alexandru Missir, Ileana Chirita, Carmen Limban, Psycholeptic-anxiolytics drugs, second edition, Tehnoplast Company Publishing House, Bucharest, 2006;
          - Alexandru Missir, Ileana Chirita, Carmen Limban, Psycholeptic-antipsychotic drugs, Tehnoplast Publishing House, Bucharest, 2002;
          - Alexandru Missir, Ileana Chirita & collab., Psychoanaleptic-antidepressant drugs, Tehnoplast Publishing House, Bucharest, 2003.


    * Pharmaceutical Biomedical Sciences
          - General Pharmacokinetics.
          - General Pharmacotoxicology.
          - Pharmacodynamic action mechanisms at cellular and molecular level.
          - Vitamins in the metabolic processes.
          - Hormones in the metabolic processes.
          - Drugs biotransformation and implications in their toxicity.
          - Drugs addiction.
          - Protein metabolic abnormalities and physiopatologic variations of the biochemical parameters.
          - The modification of biochemical parameters in the glucose metabolism abnormalities.
          - Active interest phytotherapeutic principles (flavonoids, isoflavones, tannins, saponosides and iridoids): definition, propagation, chemical structure, action and uses.


      Bibliography
          - Aurelia Nicoleta  Cristea, General Pharmacology, Didactic and Pedagogic Publishing House, Bucharest, Second edition, 2010;
          - Niculina Mitrea, Denisa Margina, Andreea Nitulescu-Arsene, Daniela Gradinaru - Biochemistry. Vitamins in the metabolic processes, Didactic and Pedagogic Publishing House, Bucharest, 2008;
          - D. Nelson, M.M. Cox Principles of Biochemistry, W.H. Freeman and Company, New York, 2008;
          - Daniela Baconi, Dan Balalau, Pavel Abraham, Abuse and drugs addiction, Medical Publishing House, Bucharest, 2008;
          - Dan Balalau, Daniela Baconi, General Toxicology, Tehnoplast Company Publishing House, Bucharest, 2005;
          - Dan Balalau, Daniela Baconi, Toxicology of the natural and related organic substances, Tehnoplast Company Publishing House, Bucharest, 2001;
          - Mihele Denisa - Medical Biochemistry, Medical Publishing House, Bucharest, 2007;
          - Viorica Istudor - Pharmacognosy, Phytochemistry, Phytotherapy, vol I, Medical Publishing House, Bucharest, 1998;
          - Viorica Istudor - Pharmacognosy, Phytochemistry, Phytotherapy, vol II, Medical Publishing House, Bucharest, 2001.


    * Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Management and Legislation
          - Modified-release tablets and capsules.
          - Transdermal preparation.
          - Parenteral preparations.
          - Availability, bioavailability and bioequivalence of medicines.
          - Compartment analysis of in toxicokinetic modeling and pharmacological phenomena.
          - Parametric statistical tests to compare data.
          - Electrical, optical and magnetic properties of molecules. Intermolecular interactions and interaction potentials. Intermolecular forces in solutions.
          - Transport processes. Mass transport. The phenomenon of diffusion.
          - Pharmaceutical Management - part of healthcare management.
          - Priority in applied research in pharmaceutical marketing.


      Bibliography
          - Iuliana Popovici, Dumitru Lupuleasa, Pharmaceutical technology, vol I, Polirom Publishing House, Bucharest, 2001;
          - Iuliana Popovici, Dumitru Lupuleasa, Pharmaceutical technology, vol II, Polirom Publishing House, Bucharest, 2008;
          - Iuliana Popovici, Dumitru Lupuleasa, Pharmaceutical technology, vol III, Polirom Publishing House, Bucharest, 2009;
          - Mircioiu Constantin, Dalia Miron, Flavian Radulescu, Cristina Ghiciuc, Ion Mircioiu, Valentina Anuta, Elements of Biopharmacy and pharmacokinetics, vol I, Fundamentals - Carol Davila University Publishing House, Bucharest, 2008;
          - Mircioiu Constantin, Roxana Sandulovici - Applied statistics in Pharmacy and clinical trials, second edition, Carol Davila University Publishing House, Bucharest, 2009;
          - Mircioiu Constantin, Roxana Sandulovici - Numerical applications in Biostatistics and Statistics Pharmacy, vol I, Manual Methods, second revised edition, Carol Davila University Publishing House, Bucharest, 2010;
          - Stefan Moisescu, Lacramioara Popa - Physical Pharmacy and Biopharmacy - Vol I - Introduction to the structure and properties of atoms and molecules. Physical Methods of Research, University Publishing House "Carol Davila", Bucharest, 2007;
          - Stefan Moisescu, Lacramioara Popa - Physical Pharmacy and Biopharmaceutics - Vol II - University Publishing House "Carol Davila", Bucharest, 2007;
          - Ana Carata - Management, Marketing and Pharmaceutical Legislation - Management in Pharmaceutic Field - Volume I, Second Edition, Didactic and Pedagogic Publishing House, Bucharest, 2008;
          - Ana Carata - Management, Marketing and Pharmaceutical Legislation - Marketing -Management in Pharmaceutic Field, Volume II, Second Edition, Tehnoplast Publishing House, Bucharest, 2009;
          - C. Florescu & collab. - Marketing, Group Marketing Academy, Bucharest, 1992.




    * Clinic and Topographyc Anatomy Topics for admission to PhD, Faculty of Dentistry
         1. Topographic and clinical anatomy of the mouth;
         2. Topographic and applied anatomy of the alveolar processes;
         3. Topographic and applied anatomy of the sinuses;
         4. Topographic and applied anatomy of peripheral trigeminal branches;
         5. Topographic and applied anatomy of the facial nerve;
         6. Topographic and applied anatomy of the temporomandibular joint - mandible;
         7. Topographic regions of the head and their relationships applied in oro-maxillo-facial practice;
         8. Topographic regions of the neck and their relationships applied in oro-maxillo-facial practice;
         9. External carotid artery in clinical and topographic anatomy;
        10. Maxillo-mandibular functional structure applied in oral implantology;


      Bibliography
         1. Gaudiya J.F. - Anatomie Clinique, Editions CdP, 2003;
         2. Nimigean V. - Clinical and topographic anatomy of the head and neck, University Publishing House "Carol Davila", Bucharest, 2004;
         3. Nimigean V., L. Podoleanu - External carotid artery, Cerma Publishing House, Bucharest, 1999;
         4. Nimigean V., Burlibasa C. - Functional anatomy of temporo-mandibular joint, Cerma Publishing House, Bucharest, 1993;
         5. Pasat I. - Head and neck anatomy, Didactic and Pedagogic Publishing House, Bucharest, 1995;
         6. Seres Sturm L. - Cervico-oro-facial anatomy, course lithographs, IMF Targu Mures, 1988;
         7. Ten Cate A.R. - Oral Histology, Mosby Company, 1994;
         8. Williams P.L. Gray's anatomy, Churchill Livingstone, New York, 1989;
      PhD Leader-Prof. Dr. Victor Nimigean

 

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